Which medication is ineffective for treating cocaine withdrawal?

Buprenorphine is a medication used primarily for treating opioid dependence, and while it may be beneficial in managing opioid withdrawal symptoms, it does not have evidence supporting its effectiveness in treating cocaine withdrawal. Cocaine withdrawal symptoms, which can include fatigue, increased appetite, depression, and agitation, do not respond to buprenorphine, as the mechanisms of withdrawal are distinct from those associated with opioids.

In contrast, other medications listed, like naltrexone, have been investigated for their potential to reduce cravings and limit the euphoric effects associated with cocaine use, even though they are not widely effective for managing acute withdrawal. Methadone and disulfiram are also not directly indicated for cocaine withdrawal but can be a part of a comprehensive treatment plan that addresses various aspects of substance use disorder.

Overall, the key to understanding why buprenorphine is not suitable for cocaine withdrawal lies in the specific pharmacological actions and the type of substance dependence being treated.